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KMID : 0371420160900040213
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Annals of Surgical Treatment and Research
2016 Volume.90 No. 4 p.213 ~ p.217
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Effect of ankaferd blood stopper in experimental peritoneal adhesion model
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Gokhan Karaca
Oktay Aydin
Faruk Pehlivanli
Ahmet Kocael
Recep Pekcici
Esat Duymus
Sukran Akgedik
Osman Guler
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Abstract
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Purpose: Ankaferd Blood Stopper (ABS) is an herbal extract attained from 5 different plants. It has the therapeutic potential to be used for the management of external hemorrhage and controlling gastrointestinal bleedings. To date, the safety of ABS for intraperitoneal usage is not clear. In this study, we investigated the effectiveness and safety of using intraperitoneal ABS in an experimental peritoneal adhesion model.
Methods: Twenty-four male Wistar Albino rats were used in the study. The rats were randomly divided into 3 groups: saline, ABS, and control. On the 10th day, all rats were euthanized. The adhesions were evaluated by Nair's macroscopic adhesion classification, and pathologically evaluated with Zuhlke's microscopic adhesion classification.
Results: macroscopic and microscopic comparison between the ABS and saline groups did not show any differences but both the ABS and saline groups were superior when compared to the control group.
Conclusion: ABS was found equally effective with saline on the abdominal adhesions and to no effect on postoperative adhesion formation.
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KEYWORD
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Ankaferd blood stopper, Rats, Intra-abdominal adhesion, Peritoneum
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